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(COD. RIC 2202) – Post-doc position in the Laboratory of Cardiovascular Pathophysiology and Regenerative Medicine

One post-doc position is open at Spinetti’s lab, IRCCS MultiMedica, Milan, Italy

One post-doc position is available in the group coordinated by Dr. Gaia Spinetti, Laboratory of Cardiovascular Pathophysiology and Regenerative Medicine at the IRCCS MultiMedica, Milan, Italy.

Spinetti’s group is conducting translational research in the field of cardiovascular diseases associated with aging. Research activities benefit from a tight collaboration with basic and clinical researchers operating at MultiMedica and with international leaders in the field of regenerative medicine such as prof Paolo Madeddu, University of Bristol, Bristol, UK.

The focus is on the micro- and macro-vascular complications of diabetes mellitus and the cardiovascular diseases associated with the geriatric syndrome of frailty. More recently COVID-19 cardiovascular complications are studied. The aim is to understand the cellular and molecular mechanisms altered in the disease status to guide personalized preventive and therapeutic strategies to regenerate damaged organs. The group is building up on a maturated experience in the pathophysiology of the bone marrow, the central organ hosting regenerative cells both of the stem/hematopoietic origin, mature immune and vascular cells involved in cardiovascular regeneration. At the molecular level special emphasis is given to inflammaging, longevity-associated proteins, and non-coding RNA functional properties.

Candidates should possess a PhD in cardiovascular biology, molecular medicine, or associated fields, Acquired skills in the following procedures are preferred:

  • multicolor flow cytometry
  • 2D and 3D cell culture
  • Immunostaining and microscopy

IRCCS MultiMedica is a center of excellence for cardiovascular research and offers a highly stimulating scientific environment that supports the close interactions between basic researchers, translational researchers, and clinicians. The Institute is equipped with advanced instrumentations for biomedical research, including a flow cytometry facility (one BD FACS CantoII/3 laser, one BD FACS Fortessa x20/5 laser, and one BD FACS AriaII Cell Sorter/3 laser)

Interested candidates should send a detailed CV, a motivation letter supporting the application to the open position, and 1-2 letters of reference (when available).

Salary will be determined according to the candidate’s expertise and CV. Interested candidates are required to send their application, using the listed email contact

gaia.spinetti@multimedica.it

List of selected publications from the last 5 years of the Spinetti’s group:

Panunzi A, Madotto F, Sangalli E, Riccio F, Sganzaroli AB, Galenda P, Bertulessi A, Barmina MF, Ludovico O, Fortunato O, Setacci F, Airoldi F, Tavano D, Giurato L, Meloni M, Uccioli L, Bruno A, Spinetti G, Caravaggi CMF. Results of a prospective observational study of autologous peripheral blood mononuclear cell therapy for no-option critical limb-threatening ischemia and severe diabetic foot ulcers. Cardiovasc Diabetol. 2022 Sep 28;21(1):196. doi: 10.1186/s12933-022-01629-y. PMID: 36171587; PMCID: PMC9516816.

Bonora BM, Palano MT, Testa G, Fadini GP, Sangalli E, Madotto F, Persico G, Casciaro F, Vono R, Colpani O, Scavello F, Cappellari R, Abete P, Orlando P, Carnelli F, Berardi AG, De Servi S, Raucci A, Giorgio M, Madeddu P, Spinetti G. Hematopoietic progenitor cell liabilities and alarmins S100A8/A9-related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults. Aging Cell. 2022 Mar;21(3):e13545. doi: 10.1111/acel.13545. Epub 2022 Feb 15. PMID: 35166014; PMCID: PMC8920446.

Mohammed SA, Albiero M, Ambrosini S, Gorica E, Karsai G, Caravaggi CM, Masi S, Camici GG, Wenzl FA, Calderone V, Madeddu P, Sciarretta S, Matter CM, Spinetti G, Lüscher TF, Ruschitzka F, Costantino S, Fadini GP, Paneni F. The BET Protein Inhibitor Apabetalone Rescues Diabetes-Induced Impairment of Angiogenic Response by Epigenetic Regulation of Thrombospondin-1. Antioxid Redox Signal. 2022 Apr;36(10-12):667-684. doi: 10.1089/ars.2021.0127. Epub 2022 Apr 1. PMID: 34913726.

Zaccagnini G, Greco S, Longo M, Maimone B, Voellenkle C, Fuschi P, Carrara M, Creo P, Maselli D, Tirone M, Mazzone M, Gaetano C, Spinetti G, Martelli F. Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia. Cell Death Dis. 2021 May 1;12(5):435. doi: 10.1038/s41419-021-03713-9. Erratum in: Cell Death Dis. 2021 May 18;12(6):507. PMID: 33934122; PMCID: PMC8088433.

Santopaolo M, Sullivan N, Thomas AC, Alvino VV, Nicholson LB, Gu Y, Spinetti G, Kallikourdis M, Blom A, Madeddu P. Activation of Bone Marrow Adaptive Immunity in Type 2 Diabetes: Rescue by Co-stimulation Modulator Abatacept. Front Immunol. 2021 Mar 4;12:609406. doi: 10.3389/fimmu.2021.609406. PMID: 33746953; PMCID: PMC7969721.

Sangalli E, Tagliabue E, Sala L, Prattichizzo F, Uccellatore A, Spada D, Lorino F, de Candia P, Lupini S, Cantone L, Favero C, Madeddu P, Bollati V, Genovese S, Spinetti G. Circulating MicroRNA-15a Associates With Retinal Damage in Patients With Early Stage Type 2 Diabetes. Front Endocrinol (Lausanne). 2020 Apr 23;11:254. doi: 10.3389/fendo.2020.00254. PMID: 32390950; PMCID: PMC7192007.

Dang Z, Avolio E, Thomas AC, Faulkner A, Beltrami AP, Cervellin C, Carrizzo A, Maciag A, Gu Y, Ciaglia E, Finato N, Damato A, Spinetti G, Alenzi A, Paisey SJ, Vecchione C, Puca AA, Madeddu P. Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway. Eur J Heart Fail. 2020 Sep;22(9):1568-1581. doi: 10.1002/ejhf.1840. Epub 2020 May 8. PMID: 32384208; PMCID: PMC8220375.

Spinetti G, Sangalli E, Tagliabue E, Maselli D, Colpani O, Ferland-McCollough D, Carnelli F, Orlando P, Paccagnella A, Furlan A, Stefani PM, Sambado L, Sambataro M, Madeddu P. MicroRNA-21/PDCD4 Proapoptotic Signaling From Circulating CD34+ Cells to Vascular Endothelial Cells: A Potential Contributor to Adverse Cardiovascular Outcomes in Patients With Critical Limb Ischemia. Diabetes Care. 2020 Jul;43(7):1520-1529. doi: 10.2337/dc19-2227. Epub 2020 May 1. PMID: 32358022; PMCID: PMC7305013.

Mangialardi G, Ferland-McCollough D, Maselli D, Santopaolo M, Cordaro A, Spinetti G, Sambataro M, Sullivan N, Blom A, Madeddu P. Bone marrow pericyte dysfunction in individuals with type 2 diabetes. Diabetologia. 2019 Jul;62(7):1275-1290. doi: 10.1007/s00125-019-4865-6. Epub 2019 Apr 17. Erratum in: Diabetologia. 2019 May 21;: PMID: 31001672; PMCID: PMC6560025.

Besnier M, Gasparino S, Vono R, Sangalli E, Facoetti A, Bollati V, Cantone L, Zaccagnini G, Maimone B, Fuschi P, Da Silva D, Schiavulli M, Aday S, Caputo M, Madeddu P, Emanueli C, Martelli F, Spinetti G. miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia. Mol Ther. 2018 Jul 5;26(7):1694-1705. doi:10.1016/j.ymthe.2018.06.003. Epub 2018 Jun 15. PMID: 29908843; PMCID: PMC6036333.

Ferland-McCollough D, Maselli D, Spinetti G, Sambataro M, Sullivan N, Blom A, Madeddu P. MCP-1 Feedback Loop Between Adipocytes and Mesenchymal Stromal Cells Causes Fat Accumulation and Contributes to Hematopoietic Stem Cell Rarefaction in the Bone Marrow of Patients With Diabetes. Diabetes. 2018 Jul;67(7):1380-1394. doi: 10.2337/db18-0044. Epub 2018 Apr 27. PMID: 29703845.